Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab27840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • MGC10182
    • Neural crest transcription factor Slug
    • Protein snail homolog 2
    • Slug (chicken homolog) zinc finger protein
    • Slug homolog zinc finger protein
    • Slug zinc finger protein
    • SLUGH
    • SLUGH 1
    • SLUGH1
    • SNAI 2
    • Snai2
    • SNAI2_HUMAN
    • Snail 2
    • Snail homolog 2
    • Snail2
    • WS 2D
    • WS2D
    • Zinc finger protein SLUG
    • Zinc finger protein SNAI2
    see all
  • Function
    Transcriptional repressor. Involved in the generation and migration of neural crest cells.
  • Tissue specificity
    Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.
  • Involvement in disease
    Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
  • Sequence similarities
    Belongs to the snail C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab27840 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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