The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions. - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer. - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent. - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised. - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Information available upon request.
Neural crest transcription factor Slug
Protein snail homolog 2
Slug (chicken homolog) zinc finger protein
Slug homolog zinc finger protein
Slug zinc finger protein
Snail homolog 2
Zinc finger protein SLUG
Zinc finger protein SNAI2
FunctionTranscriptional repressor. Involved in the generation and migration of neural crest cells.
Tissue specificityExpressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.
Involvement in diseaseDefects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
Sequence similaritiesBelongs to the snail C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.