Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab71185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 100 kDa coactivator
    • EBNA 2 co activator (100kD)
    • EBNA2 coactivator p100
    • p100
    • p100 co-activator
    • p100 coactivator
    • p100 EBNA2 co activator
    • SND 1
    • Snd1
    • SND1_HUMAN
    • Staphylococcal nuclease and tudor domain containing 1
    • Staphylococcal nuclease domain containing 1
    • Staphylococcal nuclease domain containing protein 1
    • Staphylococcal nuclease domain-containing protein 1
    • TDRD11
    • TRD 11
    • TRD11
    • Tudor domain containing protein 11
    • Tudor domain-containing protein 11
    see all
  • Function
    Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).
  • Tissue specificity
    Ubiquitously expressed.
  • Sequence similarities
    Contains 4 TNase-like domains.
    Contains 1 Tudor domain.
  • Post-translational
    modifications
    Phosphorylated by PIM1 in vitro.
  • Cellular localization
    Cytoplasm. Nucleus. Melanosome. In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

References

ab71185 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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