Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-VLRDYLSSFPFQI
    • Amino acids199 to 211

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SOCS1 antibody (ab9870)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • CISH 1
    • CISH1
    • Cytokine inducible SH2 protein 1
    • JAB
    • JAK binding protein
    • JAK-binding protein
    • Janus kinase binding protein
    • SOCS 1
    • SOCS-1
    • Socs1
    • SOCS1_HUMAN
    • SSI 1
    • SSI-1
    • SSI1
    • STAT induced STAT inhibitor 1
    • STAT-induced STAT inhibitor 1
    • Suppressor of cytokine signaling 1
    • Supressor of cytokine signalling 1
    • TEC interacting protein 3
    • Tec-interacting protein 3
    • TIP 3
    • TIP-3
    • TIP3
    see all
  • FunctionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
  • Tissue specificityExpressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • DomainThe ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box.
  • Information by UniProt

References for Human SOCS1 peptide (ab23167)

ab23167 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23167.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"