Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-SWKPQQMPPPEEPL
    • Amino acids
      385 to 398

Specifications

Our Abpromise guarantee covers the use of ab22795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • SK 1
    • SK1
    • Sphingosine kinase 1
    • SPHK
    • SPHK 1
    • Sphk1
    • SPHK1_HUMAN
    • SPK
    • SPK 1
    see all
  • Function
    Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
  • Tissue specificity
    Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.
  • Sequence similarities
    Contains 1 DAGKc domain.
  • Information by UniProt

References

ab22795 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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