Human SPTLC1 protein fragment (ab92136)
- Product nameHuman SPTLC1 protein fragmentSee all SPTLC1 proteins and peptides ...
- SourceE. coli
- Amino Acid Sequence
- SequenceLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPEL VKLKYKYKA RIFLEESLSFGVLGEHGRGVTEHYGINID DIDLISANMENALASIGGFC CGRSFVIDHQRLSGQGYC FSASLPPLLAAAAIEALNIMEENPGIFAVLK EKCGQIH KALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQE IV DQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQ TEEELERAASTIK EVAQAVLL
- Amino acids221 to 473
Our Abpromise guarantee covers the use of ab92136 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Additional NotesProtein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch)
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
- ReconstitutionReconstitute with 148 µl aqua dest.
- LCB 1
- Long chain base biosynthesis protein 1
- Serine C palmitoyltransferase
- Serine palmitoyl CoA transferase 1
- Serine palmitoyltransferase 1
- Serine palmitoyltransferase long chain base subunit 1
- Serine palmitoyltransferase subunit 1
- Serine-palmitoyl-CoA transferase 1
- SPT 1
- SPTLC 1
- FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB2 (SPTLC2 or SPTLC3) constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SSSPTB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SSSPTB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
- Tissue specificityWidely expressed. Not detected in small intestine.
- PathwayLipid metabolism; sphingolipid metabolism.
- Involvement in diseaseDefects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1A (HSAN1A) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1A is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations.
- Sequence similaritiesBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
- Cellular localizationEndoplasmic reticulum membrane.
Human SPTLC1 protein fragment images
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.
References for Human SPTLC1 protein fragment (ab92136)
ab92136 has not yet been referenced specifically in any publications.