Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-QSIDPTDSKPDSQD
    • Amino acids
      305 to 318

Associated products

Specifications

Our Abpromise guarantee covers the use of ab48061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-STAM2 antibody (ab48015)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • DKFZp564C047
    • Hbp
    • Hrs-binding protein
    • HSE1 homolog
    • Signal transducing adapter molecule 2
    • Signal transducing adaptor molecule
    • Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
    • Signal transducing adaptor molecule 2A
    • Signal transducing adaptor molecule 2B
    • STAM like protein containing SH3 and ITAM domains 2
    • STAM-2
    • Stam2
    • STAM2_HUMAN
    • STAM2A
    • STAM2B
    see all
  • Function
    Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
  • Tissue specificity
    Ubiquitously expressed.
  • Sequence similarities
    Belongs to the STAM family.
    Contains 1 ITAM domain.
    Contains 1 SH3 domain.
    Contains 1 UIM (ubiquitin-interacting motif) repeat.
    Contains 1 VHS domain.
  • Domain
    The VHS and UIM domains mediate the interaction with ubiquitinated proteins.
    The SH3 domain mediates the interaction with USP8.
    Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
  • Post-translational
    modifications
    Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
  • Cellular localization
    Cytoplasm. Early endosome membrane.
  • Information by UniProt

References

ab48061 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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