Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab26328 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Additional Notes

    ab52630

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • C1orf215
    • Lag
    • LAP 18
    • LAP18
    • LAP18
    • Leukemia associated phosphoprotein p18
    • Leukemia-associated phosphoprotein p18
    • Metablastin
    • Metablastin
    • Oncoprotein 18
    • Oncoprotein 18
    • OP 18
    • OP18
    • OP18
    • p18
    • p18
    • p19
    • p19
    • Phosphoprotein 19
    • Phosphoprotein 19
    • Phosphoprotein p19
    • PP17
    • PP19
    • PR22
    • Pr22 protein
    • Prosolin
    • Prosolin
    • Protein Pr22
    • SMN
    • Stathmin
    • Stathmin1
    • STMN 1
    • STMN1
    • STMN1
    • STMN1_HUMAN
    see all
  • FunctionInvolved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • Tissue specificityUbiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
  • Sequence similaritiesBelongs to the stathmin family.
    Contains 1 SLD (stathmin-like) domain.
  • Post-translational
    modifications
    Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • Cellular localizationCytoplasm > cytoskeleton.
  • Information by UniProt

References for Human Stathmin 1 peptide (ab26328)

ab26328 has not yet been referenced specifically in any publications.

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