Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-DAFISENGWVEDY
    • Amino acids291 to 303

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-STUB1 antibody (ab2482)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Antigen NY CO 7
    • Antigen NY-CO-7
    • C terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70 interacting protein
    • Carboxy terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70p interacting protein
    • CHIP
    • CHIP_HUMAN
    • CLL associated antigen KW 8
    • CLL-associated antigen KW-8
    • E3 ubiquitin protein ligase CHIP
    • E3 ubiquitin-protein ligase CHIP
    • Heat shock protein A binding protein 2 (c terminal)
    • HSPABP2
    • NY CO 7
    • PP1131
    • SDCCAG7
    • Serologically defined colon cancer antigen 7
    • STIP1 homology and U Box containing protein 1
    • STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase
    • STIP1 homology and U box-containing protein 1
    • STUB 1
    • STUB1
    • UBOX 1
    • UBOX1
    see all
  • FunctionE3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
  • Tissue specificityHighly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 3 TPR repeats.
    Contains 1 U-box domain.
  • DomainThe TPR domain is essential for ubiquitination mediated by UBE2D1.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human STUB1 peptide (ab45460)

ab45460 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"