Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      VDEKRKKRDIPDYLC
    • Amino acids
      281 to 232

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-STUB1 antibody (ab2917)

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human CHIP, catalog ab2917. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Antigen NY CO 7
    • Antigen NY-CO-7
    • C terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70 interacting protein
    • Carboxy terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70p interacting protein
    • CHIP
    • CHIP_HUMAN
    • CLL associated antigen KW 8
    • CLL-associated antigen KW-8
    • E3 ubiquitin protein ligase CHIP
    • E3 ubiquitin-protein ligase CHIP
    • Heat shock protein A binding protein 2 (c terminal)
    • HSPABP2
    • NY CO 7
    • PP1131
    • SDCCAG7
    • Serologically defined colon cancer antigen 7
    • STIP1 homology and U Box containing protein 1
    • STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase
    • STIP1 homology and U box-containing protein 1
    • STUB 1
    • STUB1
    • UBOX 1
    • UBOX1
    see all
  • Function
    E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
  • Tissue specificity
    Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 3 TPR repeats.
    Contains 1 U-box domain.
  • Domain
    The TPR domain is essential for ubiquitination mediated by UBE2D1.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab4934 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab4934.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up