Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-EEREKNWKEKKTTE
    • Amino acids572 to 585

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SWAP70 antibody (ab2511)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • KIAA0640
    • 70kDa
    • AV235546
    • FLJ39540
    • HSPC321
    • SWA 70 protein
    • SWAP 70
    • SWAP switching B-cell complex 70kDa subunit
    • SWAP-70
    • SWAP70
    • Switch associated protein 70
    • Switch-associated protein 70
    • SWP70_HUMAN
    see all
  • FunctionPhosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • Tissue specificityExpressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
  • Sequence similaritiesContains 1 PH domain.
  • DomainThe PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
  • Post-translational
    modifications
    Tyrosine-phosphorylated.
  • Cellular localizationCytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
  • Information by UniProt

References for Human SWAP70 peptide (ab22913)

ab22913 has not yet been referenced specifically in any publications.

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