Overview

  • Product nameHuman TBC1D4 peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceCNPNNKAKIGNKP
    • Amino acids1287 to 1299

Specifications

Our Abpromise guarantee covers the use of ab23116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Acrg embryonic lethality (mouse) minimal region ortholog
    • Acrg embryonic lethality minimal region ortholog
    • Acrg embryonic lethality mouse minimal region ortholog
    • Akt substrate of 160 kDa
    • AS 160
    • AS160
    • BUB2
    • CDC16
    • KIAA0603
    • TBC (Tre 2 BUB2 CDC16) domain containing protein
    • TBC Tre 2 BUB2 CDC16 domain containing protein
    • TBC1 D4
    • TBC1 domain family member 4
    • Tbc1d4
    • TBCD4_HUMAN
    • Tre-2
    see all
  • FunctionMay act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
  • Tissue specificityWidely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T cells from patients with atopic dermatitis.
  • Sequence similaritiesContains 2 PID domains.
    Contains 1 Rab-GAP TBC domain.
  • Post-translational
    modifications
    Phosphorylated by AKT1; insulin-induced.
    Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation.
    Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.
  • Cellular localizationCytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
  • Information by UniProt

References for Human TBC1D4 peptide (ab23116)

ab23116 has not yet been referenced specifically in any publications.

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