Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Class I cytokine receptor
    • CRL1
    • Cytokine receptor-like 1
    • I27RA_HUMAN
    • IL-27 receptor subunit alpha
    • IL-27R subunit alpha
    • IL-27R-alpha
    • IL-27RA
    • IL27R
    • IL27R alpha
    • Il27ra
    • Interleukin 27 receptor
    • Interleukin 27 receptor alpha chain precursor
    • Interleukin-27 receptor subunit alpha
    • Protein CRL1
    • T cell cytokine receptor type 1
    • TCCR
    • Type 1 T cell cytokine receptor
    • Type I T-cell cytokine receptor
    • WSX-1
    • WSX1
    • ZcytoR1
    see all
  • FunctionReceptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • Tissue specificityHighly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 3 fibronectin type-III domains.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Human TCCR peptide (ab39872)

ab39872 has not yet been referenced specifically in any publications.

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