Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab38395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • anti TCL1A
    • Lymphoma/leukemia, T-cell
    • Oncogene TCL-1
    • Oncogene TCL1
    • P14 TCL1
    • P14 TCL1 protein
    • Protein p14 TCL1
    • T cell leukemia 1
    • T cell lymphoma 1
    • T cell lymphoma 1A
    • T-cell leukemia/lymphoma protein 1A
    • TCL 1 protein
    • TCL1
    • TCL1 oncogene
    • TCL1 PEN
    • TCL1A
    • TCL1A antibody
    • TCL1A_HUMAN
    see all
  • FunctionEnhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
  • Tissue specificityRestricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • Involvement in diseaseNote=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
  • Sequence similaritiesBelongs to the TCL1 family.
  • Cellular localizationCytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
  • Target information above from: UniProt accession P56279 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for Human Tcl1 peptide (ab38395)

This product has been referenced in:
  • LaPan P  et al. Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum. BMC Pulm Med 10:40 (2010). ELISA . Read more (PubMed: 20678199) »

See 1 Publication for this product

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