The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Thrombopoietin antibody (ab40664)
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
ReconstitutionReconstitute the peptide with a small volume of either ethanol:water (20:80 / v:v) or with acetonitrile:water (20:80 / v:v) and then dilute the stock peptide into the appropriate buffer for use.
C mpl ligand
Megakaryocyte colony stimulating factor
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
Megakaryocyte stimulating factor
Myeloproliferative leukemia virus oncogene ligand
Thrombopoietin nirs variant 1
FunctionLineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Involvement in diseaseDefects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
Sequence similaritiesBelongs to the EPO/TPO family.
DomainTwo-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.