Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequencePPTGQYTLFP LPPTLPTPVV QLHPLLPDPS APTP
    • Amino acids299 to 332

Associated products

Specifications

Our Abpromise guarantee covers the use of ab93626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Thrombopoietin antibody (ab40664)

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • ReconstitutionReconstitute the peptide with a small volume of either ethanol:water (20:80 / v:v) or with acetonitrile:water (20:80 / v:v) and then dilute the stock peptide into the appropriate buffer for use.

General Info

  • Alternative names
    • C mpl ligand
    • C-mpl ligand
    • Megakaryocyte colony stimulating factor
    • Megakaryocyte colony-stimulating factor
    • Megakaryocyte growth and development factor
    • Megakaryocyte stimulating factor
    • MGC163194
    • MGDF
    • MKCSF
    • ML
    • MPL ligand
    • MPLLG
    • Myeloproliferative leukemia virus oncogene ligand
    • Prepro thrombopoietin
    • THCYT1
    • THPO
    • Thrombopoietin
    • Thrombopoietin nirs variant 1
    • TPO
    • TPO_HUMAN
    see all
  • FunctionLineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • Involvement in diseaseDefects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
  • Sequence similaritiesBelongs to the EPO/TPO family.
  • DomainTwo-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Human Thrombopoietin peptide (ab93626)

ab93626 has not yet been referenced specifically in any publications.

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