The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Thromboxane synthase antibody (ab39362)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Cytochrome P450 5A1
Cytochrome P450, family 5, subfamily A, polypeptide 1
Platelet cytochrome P450 subfamily V
Thromboxane A synthase 1
Thromboxane A synthase 1 (platelet)
Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
Thromboxane A synthase 1 platelet cytochrome P450 subfamily V
Tissue specificityPlatelets, lung, kidney, spleen, macrophages and lung fibroblasts.
Involvement in diseaseDefects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all. Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis.
Sequence similaritiesBelongs to the cytochrome P450 family.