Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceKETRNMVQRQFIA
    • Amino acids223 to 235

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ab39885 peptide blocks antibodies that recognise amino acids 223-235 of human TICAM-2.
  • Applications

    Western blot

    Blocking - Blocking peptide for Anti-TICAM2 antibody (ab17221)

  • FormLiquid
  • Additional notesStable for at least 1 year at -20°C.The ab39885 peptide blocks antibodies that recognise amino acids 223-235 of human TICAM-2.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Putative NF-kappa-B-activating protein 502
    • TCAM2_HUMAN
    • TICAM-2
    • TICAM2
    • TIR containing adapter molecule 2
    • TIR domain containing adaptor protein
    • TIR domain-containing adapter molecule 2
    • TIRAP 3
    • TIRAP3
    • TIRAP3a short form
    • TIRP
    • Toll-like receptor adaptor protein 3
    • Toll/interleukin-1 receptor domain-containing protein
    • TRAM
    • TRIF-related adapter molecule
    see all
  • FunctionFunctions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • Tissue specificityExpressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • Sequence similaritiesContains 1 TIR domain.
  • DomainThe TIR domain mediates the interaction with TRAF6.
  • Post-translational
    modifications
    Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • Cellular localizationCytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt

References for Human TICAM2 peptide (ab39885)

ab39885 has not yet been referenced specifically in any publications.

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