Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-RESQSYLVEDLERS
    • Amino acids182 to 195

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TMS1 antibody (ab2236)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Apoptosis associated speck like protein containing a CARD
    • Apoptosis-associated speck-like protein containing a CARD
    • ASC
    • ASC_HUMAN
    • CARD 5
    • CARD5
    • Caspase recruitment domain containing protein 5
    • Caspase recruitment domain protein 5
    • Caspase recruitment domain-containing protein 5
    • hASC
    • MGC10332
    • PYCARD
    • PYD and CARD domain containing
    • PYD and CARD domain containing protein
    • PYD and CARD domain-containing protein
    • Target of methylation induced silencing 1
    • Target of methylation-induced silencing 1
    • TMS
    • TMS 1
    • TMS1
    see all
  • FunctionPromotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • Tissue specificityWidely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.
  • Sequence similaritiesContains 1 CARD domain.
    Contains 1 DAPIN domain.
  • DomainInteracts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localizationCytoplasm. Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
  • Information by UniProt

References for Human TMS1 peptide (ab22875)

ab22875 has not yet been referenced specifically in any publications.

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