Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-NKPNSGKNDDKGNK
    • Amino acids37 to 50

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TPH2 antibody (ab40846)

  • FormLiquid
  • Additional notes

    ab40846 Anti-TPH2 antibody is the corresponding antibody to this peptide.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • MGC138871
    • ADHD7
    • FLJ37295
    • MGC138872
    • Neuronal tryptophan hydroxylase
    • NTPH
    • TPH 2
    • Tph2
    • TPH2_HUMAN
    • Tryptophan 5-hydroxylase 2
    • Tryptophan 5-monooxygenase 2
    • Tryptophan hydroxylase 2
    see all
  • Tissue specificityBrain specific.
  • PathwayAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
  • Involvement in diseaseGenetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
    Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
  • Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    Contains 1 ACT domain.
  • Information by UniProt

References for Human TPH2 peptide (ab45838)

ab45838 has not yet been referenced specifically in any publications.

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