The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-TPH2 antibody (ab40846)
ab40846 Anti-TPH2 antibody is the corresponding antibody to this peptide.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Neuronal tryptophan hydroxylase
Tryptophan 5-hydroxylase 2
Tryptophan 5-monooxygenase 2
Tryptophan hydroxylase 2
Tissue specificityBrain specific.
PathwayAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
Involvement in diseaseGenetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516]. Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
Sequence similaritiesBelongs to the biopterin-dependent aromatic amino acid hydroxylase family. Contains 1 ACT domain.