Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-TMKKLKLISSDSED
    • Amino acids406 to 419

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TRF1 antibody (ab2447)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • hTRF1 AS
    • NIMA interacting protein 2
    • NIMA-interacting protein 2
    • PIN 2
    • PIN2
    • t TRF1
    • Telomeric protein Pin2
    • Telomeric protein Pin2/TRF1
    • Telomeric repeat binding factor (NIMA interacting) 1
    • Telomeric repeat binding factor 1
    • Telomeric repeat binding protein 1
    • Telomeric repeat-binding factor 1
    • TERF 1
    • Terf1
    • TERF1_HUMAN
    • TRBF 1
    • TRBF1
    • TRF
    • TRF 1
    • TTAGGG repeat binding factor 1
    • TTAGGG repeat-binding factor 1
    see all
  • FunctionBinds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
  • Tissue specificityHighly expressed and ubiquitous. Isoform Pin2 predominates.
  • Sequence similaritiesContains 1 HTH myb-type DNA-binding domain.
  • DomainThe acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.
    The TRFH dimerization region mediates the interaction with TINF2.
  • Post-translational
    modifications
    Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
    ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.
    Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
  • Cellular localizationNucleus. Cytoplasm > cytoskeleton > spindle. Chromosome > telomere. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.
  • Information by UniProt

References for Human TRF1 peptide (ab22905)

ab22905 has not yet been referenced specifically in any publications.

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