Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-LNSLNQAVVSKLA
    • Amino acids421 to 443

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TRIP15 antibody (ab4537)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • ALIEN
    • Alien Drosophila himolog of
    • Alien homolog
    • COP 9
    • COP9
    • COP9 constitutive photomorphogenic homolog subunit 2
    • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
    • COP9 signalosome complex subunit 2
    • COPS 2
    • Cops2
    • CSN2
    • CSN2_HUMAN
    • JAB1 containing signalosome subunit 2
    • JAB1-containing signalosome subunit 2
    • SGN 2
    • SGN2
    • Signalosome subunit 2
    • Thyroid Hormone Receptor Interactor15
    • Thyroid Hormone Receptor Interactor 15
    • Thyroid receptor-interacting protein 15
    • TR-interacting protein 15
    • TRIP 15
    • TRIP-15
    • TRIP15
    see all
  • FunctionEssential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • Sequence similaritiesBelongs to the CSN2 family.
    Contains 1 PCI domain.
  • Post-translational
    modifications
    Phosphorylated by CK2 and PKD kinases.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

References for Human TRIP15 peptide (ab23046)

ab23046 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23046.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"