Overview

  • Product name
    Human TXNIP peptide

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab97419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • EST01027
    • HHCPA78
    • THIF
    • Thioredoxin binding protein 2
    • Thioredoxin interacting protein
    • Thioredoxin-binding protein 2
    • Thioredoxin-interacting protein
    • TXNIP
    • TXNIP_HUMAN
    • Upregulated by 1,25 dihydroxyvitamin D 3
    • VDUP1
    • Vitamin D3 up-regulated protein 1
    see all
  • Function
    May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
  • Sequence similarities
    Belongs to the arrestin family.
  • Post-translational
    modifications
    Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab97419 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


We have been informed that reversed phase C18 HPLC columns were used. The eluent is a mixture of water, acetonitrile/iso-Propanol (1:1) and 0.1% TFA. The gradient depends on the hydrophobicity of the peptides.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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