Overview

  • Product nameHuman TXNIP peptide

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab97419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TXNIP antibody (ab86983)

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • EST01027
    • HHCPA78
    • THIF
    • Thioredoxin binding protein 2
    • Thioredoxin interacting protein
    • Thioredoxin-binding protein 2
    • Thioredoxin-interacting protein
    • TXNIP
    • TXNIP_HUMAN
    • Upregulated by 1,25 dihydroxyvitamin D 3
    • VDUP1
    • Vitamin D3 up-regulated protein 1
    see all
  • FunctionMay act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
  • Sequence similaritiesBelongs to the arrestin family.
  • Post-translational
    modifications
    Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Human TXNIP peptide (ab97419)

ab97419 has not yet been referenced specifically in any publications.

Product Wall


We have been informed that reversed phase C18 HPLC columns were used. The eluent is a mixture of water, acetonitrile/iso-Propanol (1:1) and 0.1% TFA. The gradient depends on the hydrophobicity of the peptides.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"