Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39894 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ab39894 peptide blocks antibodies that recognise 15 amino acids near the C-terminus of human Ube2N.
  • Applications

    Blocking - Blocking peptide for Anti-Ube2N / Ubc13 antibody (ab25885)

    Western blot

  • FormLiquid
  • Additional notesStable for at least 1 year at -20°C to -70°C.The ab39894 peptide blocks antibodies that recognise 15 amino acids near the C-terminus of human Ube2N.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Bendless like ubiquitin conjugating enzyme
    • Bendless-like ubiquitin-conjugating enzyme
    • BLU
    • EC 6.3.2.19
    • Epididymis secretory protein Li 71
    • HEL-S-71
    • Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds
    • MGC131857
    • MGC8489
    • UBC 13
    • Ubc13
    • UbCH ben
    • UbcH-ben
    • UbcH13
    • UBCHBEN
    • Ube 2N
    • Ube2n
    • UBE2N_HUMAN
    • Ubiquitin carrier protein N
    • Ubiquitin conjugating enzyme E2 N
    • Ubiquitin conjugating enzyme E2N
    • Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13)
    • Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast)
    • Ubiquitin protein ligase N
    • Ubiquitin-conjugating enzyme E2 N
    • Ubiquitin-protein ligase N
    • Yeast UBC13 homolog
    see all
  • FunctionThe UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the ubiquitin-conjugating enzyme family.
  • Post-translational
    modifications
    Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.
  • Cellular localizationNucleus. Cytoplasm.
  • Information by UniProt

References for Human Ube2N / Ubc13 peptide (ab39894)

ab39894 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab39894.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"