Human UBR1 peptide (ab42419)
- Product nameHuman UBR1 peptideSee all UBR1 proteins and peptides ...
Our Abpromise guarantee covers the use of ab42419 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Information available upon request.
- E3 ubiquitin-protein ligase UBR1
- ubiquitin protein ligase E3 component n-recognin 1
- Ubiquitin-protein ligase E3-alpha-1
- Ubiquitin-protein ligase E3-alpha-I
- FunctionE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
- Tissue specificityBroadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
- PathwayProtein modification; protein ubiquitination.
- Involvement in diseaseDefects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS) [MIM:243800]. This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis.
- Sequence similaritiesBelongs to the UBR1 family.
Contains 1 RING-type zinc finger.
Contains 1 UBR-type zinc finger.
- Developmental stageExpressed in fetal pancreas.
- DomainThe RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationCytoplasm > cytosol.
References for Human UBR1 peptide (ab42419)
ab42419 has not yet been referenced specifically in any publications.