The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Deubiquitinating enzyme 11
Ubiquitin carboxyl-terminal hydrolase 11
Ubiquitin carboxyl-terminal hydrolase X linked
ubiquitin specific peptidase 11
Ubiquitin specific protease 11
Ubiquitin thiolesterase 11
Ubiquitin-specific-processing protease 11
FunctionProtease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.
Sequence similaritiesBelongs to the peptidase C19 family. Contains 1 DUSP domain.
Cellular localizationNucleus. Cytoplasm. Predominantly nuclear. Associates with chromatin.