Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      PLYSVTVKWGKEK-C
    • Amino acids
      2 to 14

Specifications

Our Abpromise guarantee covers the use of ab23055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Deubiquitinating enzyme 14
    • TGT
    • tRNA guanine transglycosylase
    • tRNA guanine transglycosylase 60 kD subunit
    • Ubiquitin carboxyl terminal hydrolase 14
    • Ubiquitin carboxyl-terminal hydrolase 14
    • Ubiquitin specific peptidase 14
    • Ubiquitin specific processing protease 14
    • Ubiquitin specific protease 14
    • Ubiquitin thiolesterase 14
    • Ubiquitin-specific-processing protease 14
    • UBP14_HUMAN
    • USP 14
    • USP14
    see all
  • Function
    Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
  • Sequence similarities
    Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
    Contains 1 ubiquitin-like domain.
  • Cellular localization
    Cytoplasm. Cell membrane.
  • Information by UniProt

References

ab23055 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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