Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-HGEQKIEAETRAV
    • Amino acids901 to 913

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-USP20 antibody (ab5272)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Deubiquitinating enzyme 20
    • hVDU2
    • KIAA1003
    • LSFR 3A
    • LSFR3A
    • pVHL interacting deubiquitinating enzyme 2
    • Ubiquitin carboxyl terminal hydrolase 20
    • Ubiquitin carboxyl-terminal hydrolase 20
    • ubiquitin specific peptidase 20
    • Ubiquitin specific processing protease 20
    • Ubiquitin specific protease 20
    • Ubiquitin thioesterase 20
    • Ubiquitin thiolesterase 20
    • Ubiquitin-specific-processing protease 20
    • UBP20_HUMAN
    • USP 20
    • USP20
    • VDU 2
    • VDU2
    • VHL interacting deubiquitinating enzyme 2
    • VHL-interacting deubiquitinating enzyme 2
    see all
  • FunctionDeubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • Sequence similaritiesBelongs to the peptidase C19 family. USP20/USP33 subfamily.
    Contains 2 DUSP domains.
    Contains 1 UBP-type zinc finger.
  • DomainThe UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue.
  • Post-translational
    modifications
    Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
  • Cellular localizationCytoplasm > perinuclear region. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
  • Information by UniProt

References for Human USP20 peptide (ab23089)

ab23089 has not yet been referenced specifically in any publications.

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