Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-YVEHQAKAGSDKL
    • Amino acids
      508 to 520

Specifications

Our Abpromise guarantee covers the use of ab23058 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Deubiquitinating enzyme 3
    • EC 3.1.2.15
    • SIH003
    • Ubiquitin carboxyl-terminal hydrolase 3
    • Ubiquitin specific peptidase 3
    • Ubiquitin specific processing protease 3
    • Ubiquitin Specific Protease 3
    • Ubiquitin thioesterase 3
    • Ubiquitin thiolesterase 3
    • Ubiquitin-specific-processing protease 3
    • UBP
    • UBP3_HUMAN
    • Usp3
    see all
  • Function
    Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
  • Tissue specificity
    Expressed in all tissues examined, with strongest expression in pancreas.
  • Sequence similarities
    Belongs to the peptidase C19 family. USP3 subfamily.
    Contains 1 UBP-type zinc finger.
  • Domain
    Both protease activity and an intact zinc finger are required for H2A monodeubiquitination.
  • Cellular localization
    Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.
  • Information by UniProt

References

ab23058 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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