Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-YVEHQAKAGSDKL
    • Amino acids508 to 520

Specifications

Our Abpromise guarantee covers the use of ab23058 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Deubiquitinating enzyme 3
    • EC 3.1.2.15
    • SIH003
    • Ubiquitin carboxyl-terminal hydrolase 3
    • Ubiquitin specific peptidase 3
    • Ubiquitin specific processing protease 3
    • Ubiquitin Specific Protease 3
    • Ubiquitin thioesterase 3
    • Ubiquitin thiolesterase 3
    • Ubiquitin-specific-processing protease 3
    • UBP
    • UBP3_HUMAN
    • Usp3
    see all
  • FunctionHydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
  • Tissue specificityExpressed in all tissues examined, with strongest expression in pancreas.
  • Sequence similaritiesBelongs to the peptidase C19 family. USP3 subfamily.
    Contains 1 UBP-type zinc finger.
  • DomainBoth protease activity and an intact zinc finger are required for H2A monodeubiquitination.
  • Cellular localizationNucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.
  • Information by UniProt

References for Human USP3 peptide (ab23058)

ab23058 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23058.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"