Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      AEGGGCRERPDAE
    • Amino acids
      2 to 14

Specifications

Our Abpromise guarantee covers the use of ab23051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Deubiquitinating enzyme 4
    • MGC149848
    • MGC149849
    • Proto oncogene
    • Protooncogene
    • Ubiquitin carboxyl terminal hydrolase 4
    • Ubiquitin carboxyl-terminal hydrolase 4
    • Ubiquitin specific peptidase 4
    • Ubiquitin specific peptidase 4 (proto oncogene)
    • Ubiquitin specific peptidase 4 (protooncogene)
    • Ubiquitin specific processing protease 4
    • Ubiquitin specific protease 4
    • Ubiquitin specific protease 4 (proto oncogene)
    • Ubiquitin specific protease 4 (protooncogene)
    • Ubiquitin specific protease proto oncogene
    • Ubiquitin specific protease protooncogene
    • Ubiquitin thioesterase 4
    • Ubiquitin thiolesterase 4
    • Ubiquitin-specific-processing protease 4
    • Ubiquitous nuclear protein homolog
    • UBP4_HUMAN
    • UNP
    • UNPH
    • USP 4
    • USP4
    see all
  • Function
    Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
  • Tissue specificity
    Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
  • Sequence similarities
    Belongs to the peptidase C19 family. USP4 subfamily.
    Contains 1 DUSP domain.
  • Post-translational
    modifications
    Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
  • Cellular localization
    Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.
  • Information by UniProt

References

ab23051 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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