The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Deubiquitinating enzyme 4
Ubiquitin carboxyl terminal hydrolase 4
Ubiquitin carboxyl-terminal hydrolase 4
Ubiquitin specific peptidase 4
Ubiquitin specific peptidase 4 (proto oncogene)
Ubiquitin specific peptidase 4 (protooncogene)
Ubiquitin specific processing protease 4
Ubiquitin specific protease 4
Ubiquitin specific protease 4 (proto oncogene)
Ubiquitin specific protease 4 (protooncogene)
Ubiquitin specific protease proto oncogene
Ubiquitin specific protease protooncogene
Ubiquitin thioesterase 4
Ubiquitin thiolesterase 4
Ubiquitin-specific-processing protease 4
Ubiquitous nuclear protein homolog
FunctionHydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
Tissue specificityOverexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
Sequence similaritiesBelongs to the peptidase C19 family. USP4 subfamily. Contains 1 DUSP domain.
Post-translational modificationsMonoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
Cellular localizationCytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.