Human VDAC1 / Porin peptide (ab16131)

Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab16131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-VDAC1 / Porin antibody - Mitochondrial Loading Control (ab15895), Anti-VDAC1/Porin antibody (HRP) - Mitochondrial Loading Control (ab40747)

  • Purity70 - 90% by HPLC.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General info

  • Alternative names
    • hVDAC1
    • MGC111064
    • Mitochondrial Porin
    • Outer mitochondrial membrane protein porin 1
    • Plasmalemmal porin
    • Porin
    • Porin 31HL
    • Porin 31HM
    • PORIN-31-HL
    • VDAC
    • VDAC 1
    • VDAC-1
    • Vdac1
    • VDAC1_HUMAN
    • Voltage Dependent Anion Channel 1
    • Voltage dependent anion selective channel protein 1
    • Voltage-dependent anion-selective channel protein 1
    see all
  • FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • Tissue specificityHeart, liver and skeletal muscle.
  • Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
  • DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • Cellular localizationMitochondrion outer membrane. Cell membrane.
  • Information by UniProt

References for Human VDAC1 / Porin peptide (ab16131)

ab16131 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry and your interest in our products. We would like to confirm that ab16131 is a blocking peptide which can be used with ab3434:VDAC1 / Porin primary antibody for Western blot application.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"