Human VDAC1 / Porin peptide (ab16131)
- Product nameHuman VDAC1 / Porin peptideSee all VDAC1 / Porin proteins and peptides ...
- Amino Acid Sequence
Our Abpromise guarantee covers the use of ab16131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- Purity70 - 90% by HPLC.
- Concentration information loading...
Preparation and Storage
- Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Information available upon request.
- Mitochondrial Porin
- Outer mitochondrial membrane protein porin 1
- Plasmalemmal porin
- Porin 31HL
- Porin 31HM
- VDAC 1
- Voltage Dependent Anion Channel 1
- Voltage dependent anion selective channel protein 1
- Voltage-dependent anion-selective channel protein 1
- FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
- Tissue specificityHeart, liver and skeletal muscle.
- Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
- DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
- Cellular localizationMitochondrion outer membrane. Cell membrane.
References for Human VDAC1 / Porin peptide (ab16131)
ab16131 has not yet been referenced specifically in any publications.