Overview

  • Product nameHuman VDAC1 / Porin peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab95341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity70 - 90% by HPLC.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • ReconstitutionReconstitute with sterile distilled water

General Info

  • Alternative names
    • hVDAC1
    • Outer mitochondrial membrane protein porin 1
    • Plasmalemmal porin
    • Porin
    • Porin 31HL
    • Porin 31HM
    • VDAC
    • VDAC 1
    • VDAC-1
    • Vdac1
    • VDAC1_HUMAN
    • Voltage Dependent Anion Channel 1
    • Voltage dependent anion selective channel protein 1
    • Voltage-dependent anion-selective channel protein 1
    see all
  • FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • Tissue specificityHeart, liver and skeletal muscle.
  • Sequence similaritiesBelongs to the eukaryotic mitochondrial porin family.
  • DomainConsists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • Cellular localizationMitochondrion outer membrane. Cell membrane.
  • Information by UniProt

References for Human VDAC1 / Porin peptide (ab95341)

ab95341 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95341.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"