Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] (ab90341)

Overview

  • Product nameAnti-Huntingtin Interacting Protein HIP1 antibody [1B11]
    See all Huntingtin Interacting Protein HIP1 primary antibodies
  • Description
    Mouse monoclonal [1B11] to Huntingtin Interacting Protein HIP1
  • Tested applicationsSuitable for: WB, ELISA, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to C terminal half of Human Huntingtin Interacting Protein HIP1.

  • Positive control
    • PC-3 cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number1B11
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.125 µg/ml. Predicted molecular weight: 116 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Target

  • FunctionPlays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • Tissue specificityUbiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
  • Involvement in diseaseNote=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
  • Sequence similaritiesBelongs to the SLA2 family.
    Contains 1 ENTH (epsin N-terminal homology) domain.
    Contains 1 I/LWEQ domain.
  • DomainThe pseudo DED region (pDED) mediates the interaction with IFT57.
    Binds F-actin via the talin-like I/LWEQ domain.
  • Cellular localizationCytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2610109B09Rik antibody
    • A930014B11Rik antibody
    • E130315I21Rik antibody
    • HIP 1 antibody
    • HIP I antibody
    • HIP-1 antibody
    • HIP-I antibody
    • hip1 antibody
    • HIP1/PDGFRB fusion gene antibody
    • HIP1/PDGFRB fusion gene, included antibody
    • HIP1_HUMAN antibody
    • HIPI antibody
    • Huntingtin interacting protein 1 antibody
    • Huntingtin-interacting protein 1 antibody
    • Huntingtin-interacting protein I antibody
    • ILWEQ antibody
    • KIAA4113 antibody
    • MGC126506 antibody
    • MGC27616 antibody
    • mKIAA4113 antibody
    see all

Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] images

  • All lanes : Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] (ab90341) at 0.125 µg/ml

    Lane 1 : PC-3 cell lysate
    Lane 2 : Recombinant protein at 0.02 µg
    Lane 3 : Recombinant protein at 0.04 µg


    Predicted band size : 116 kDa

References for Anti-Huntingtin Interacting Protein HIP1 antibody [1B11] (ab90341)

ab90341 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your response.

My colleague Padamjeet is out of office today. I would advise you to check the on-line datasheet for this product since it has the price, unit size, tested species and applications on the document.

For f...

Read More

Thank you for contacting us.

I am sorry to hear you are experiencing difficulties with one of our products. We take product complaints very seriously, and investigate every product that we feel may not be performing correctly.

I am at...

Read More

Thank you for contacting us. Because we carry over 70,000 products, it isn't feasible for us to keep small sample sizes of our products.

We are happy to reassure our customers that all of our products are covered by our Abpromise, which guaran...

Read More

Thank you for contacting us.

Please find attached the datasheet.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our products? Submit an Abreview...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"