Overview

  • Product name
  • Description
    Rabbit polyclonal to HURP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (HKEYERNRHF GLKDVNIPTL EGRILVELDE TSQELVPEKT NVKPRAMKTI) of Human HURP (NP_055565)

  • Positive control
    • Transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab80684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 94 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
  • Tissue specificity
    Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
  • Sequence similarities
    Belongs to the SAPAP family.
  • Developmental stage
    Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.
  • Post-translational
    modifications
    Ubiquitinated, leading to its degradation.
    Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
  • Cellular localization
    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton > spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAP-5 antibody
    • DAP5 antibody
    • Discs large homolog 7 antibody
    • Disks large associated protein 5 antibody
    • Disks large associated protein DLG7 antibody
    • Disks large-associated protein 5 antibody
    • Disks large-associated protein DLG7 antibody
    • DLG 1 antibody
    • DLG 7 antibody
    • DLG1 antibody
    • DLG7 antibody
    • DLGAP5 antibody
    • DLGP5_HUMAN antibody
    • Drosophila discs large 1 tumor suppressor like antibody
    • Hepatoma up regulated protein antibody
    • Hepatoma up-regulated protein antibody
    • Hepatoma upregulated protein antibody
    • HURP antibody
    • KIAA0008 antibody
    see all

Images

  • Anti-HURP antibody (ab80684) at 1 µg/ml (in 5% skim milk / PBS buffer) + transfected 293T cell lysate at 10 µg

    Secondary
    HRP-conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 94 kDa
    Observed band size : 94 kDa

References

ab80684 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab80684.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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