Anti-HURP antibody - Aminoterminal end (ab79870)

Overview

  • Product name
    Anti-HURP antibody - Aminoterminal end
    See all HURP primary antibodies
  • Description
    Rabbit polyclonal to HURP - Aminoterminal end
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the N-terminal region of human HURP.

  • Positive control
    • RAMOS cytoplasmic or nuclear lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab79870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 94 kDa (predicted molecular weight: 94 kDa).
ELISA 1/1000.

Target

  • Function
    Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
  • Tissue specificity
    Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
  • Sequence similarities
    Belongs to the SAPAP family.
  • Developmental stage
    Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.
  • Post-translational
    modifications
    Ubiquitinated, leading to its degradation.
    Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
  • Cellular localization
    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton > spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAP-5 antibody
    • DAP5 antibody
    • Discs large homolog 7 antibody
    • Disks large associated protein 5 antibody
    • Disks large associated protein DLG7 antibody
    • Disks large-associated protein 5 antibody
    • Disks large-associated protein DLG7 antibody
    • DLG 1 antibody
    • DLG 7 antibody
    • DLG1 antibody
    • DLG7 antibody
    • DLGAP5 antibody
    • DLGP5_HUMAN antibody
    • Drosophila discs large 1 tumor suppressor like antibody
    • Hepatoma up regulated protein antibody
    • Hepatoma up-regulated protein antibody
    • Hepatoma upregulated protein antibody
    • HURP antibody
    • KIAA0008 antibody
    see all

Images

  • Anti-HURP antibody - Aminoterminal end (ab79870) at 1/50 dilution + RAMOS cell line lysate at 35 µg

    Predicted band size : 94 kDa
    Observed band size : 94 kDa

References

ab79870 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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