![Immunoprecipitation - hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11] (ab110297) image](#hydroxysteroid-17-beta-dehydrogenase-4-Primary-antibodies-ab110297-1.jpg)
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Product name
Anti-hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11]
See all Hydroxysteroid (17-beta) Dehydrogenase 4 products (5) ...
Description
Mouse monoclonal [8E5AB11] to hydroxysteroid (17-beta) dehydrogenase 4
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Human liver mitochondria
Positive control
Human Liver Microsomes.
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: HBS
Concentration
Concentration information loading...
Purity
Ammonium Sulphate Precipitation
Purification notes
ab110297 is produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Clonality
Monoclonal
Clone number
8E5AB11
Isotype
IgG3
Light chain type
kappa
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Lipid and lipoprotein metabolism >> Fatty acids
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Metabolism
Cancer >> Tumor biomarkers >> Enzymes >> Other
Signal Transduction >> Metabolism >> Lipid metabolism
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Immunoprecipitation - hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11] (ab110297)
![Immunoprecipitation - hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11] (ab110297) image](/ps/datasheet/images/110/ab110297/hydroxysteroid-17-beta-dehydrogenase-4-Primary-antibodies-ab110297-1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab110297 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent dilution.
Target
Function
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.
Tissue specificity
Present in many tissues with highest concentrations in liver, heart, prostate and testis.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Involvement in disease
Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.
Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Contains 1 MaoC-like domain.
Contains 1 SCP2 domain.
Cellular localization
Peroxisome.
Target information above from: UniProt accessionP51659
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase antibody
- 17 beta HSD 4 antibody
- 17 beta HSD IV antibody
see all
Database links
- Entrez Gene: 3295 Human
- Omim: 601860 Human
- SwissProt: P51659 Human
- Unigene: 406861 Human
Anti-hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11] images:
Immunoprecipitation - hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11] (ab110297)
Immunoprecipitation with ab110297 from Human Liver Microsomes.
References for Anti-hydroxysteroid (17-beta) dehydrogenase 4 antibody [8E5AB11] (ab110297)
ab110297 has not yet been referenced specifically in any publications.
Publishing research using ab110297? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"