Overview

  • Product name
    Hydroxytacrine maleate
  • Description
    Cholinesterase inhibitor
  • Alternative names
    • 1-Hydroxytacrine
    • 9-Amino-1,2,3,4-tetrahydro-1-acridinol (2Z)-2-butenedioate
    • 9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate
    • HP 029
    • P 83-6029A
    • Velnacrine maleate
    see all
  • Biological description

    Cholinesterase inhibitor. Potential Alzheimer’s therapeutic of low toxicity. Bioactive monohydroxylated metabolite of tacrine with similar anticholinesterase activity, but displays less acute toxicity in animals. Inhibits Acetylcholine esterase.

  • Purity
    > 98%

Properties

  • Chemical name
    9-Amino-1,2,3,4-tetrahydroacridin-1-ol maleate
  • Molecular weight
    330.30
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C13H14N2O.C4H4O4
  • CAS Number
    118909-22-1
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 10 mM (with warming), in DMSO to 75 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Hansen LL  et al. Determination of tacrine and its metabolites in human plasma and urine by high-performance liquid chromatography and fluorescence detection. J Chromatogr B Biomed Sci Appl 712:183-91 (1998). Read more (PubMed: 9698241) »
  • Shutske GM  et al. 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics. J Med Chem 32:1805-13 (1989). Read more (PubMed: 2754707) »
  • Shutske GM  et al. (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity. J Med Chem 31:1278-9 (1988). Read more (PubMed: 3385720) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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