Overview

  • Product name
    Iberiotoxin
  • Description
    Selective blocker of the high-conductance, Ca2+-activated K+ channel
  • Biological description
    Selective blocker of the high-conductance, Ca2+-activated K+ channel. Originally isolated from the scorpion Mesobuthus tamulus. Specifically blocks KCa1.1 (Slo) channels (Ki approx. 1 nM).
  • Purity
    > 95%

Properties

Images

  • HEK293 cells plated for 48 hours and then transfected with rat Slo27 for 24 hours. Currents from whole-cell recordings, with 1 µM Ca2+ in the electrode solution. Cells voltage-clamped at -80 mV, with currents activated by 500 ms depolarization to +20 mV. Concentration-inhibition relationship produces an IC50 of 412 pM.

    (Number of experimental determinations shown in brackets).

References

This product has been referenced in:
  • Meera P  et al. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Proc Natl Acad Sci U S A 97:5562-7 (2000). Read more (PubMed: 10792058) »
  • Koschak A  et al. [125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels. Biochemistry 36:1943-52 (1997). Read more (PubMed: 9048582) »
  • Garcia ML  et al. Use of toxins to study potassium channels. J Bioenerg Biomembr 23:615-46 (1991). Read more (PubMed: 1917911) »

See all 3 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120379.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up