Overview

  • Product nameAnti-IBRDC2 antibody
    See all IBRDC2 primary antibodies
  • Description
    Mouse monoclonal to IBRDC2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF , corresponding to amino acids 1-101 of Human IBRDC2

Properties

Applications

Our Abpromise guarantee covers the use of ab57246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
    • Tissue specificityBroadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesBelongs to the RBR family. RNF144 subfamily.
      Contains 1 IBR-type zinc finger.
      Contains 2 RING-type zinc fingers.
    • DomainThe RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis.
    • Post-translational
      modifications
      Auto-ubiquitinated.
    • Cellular localizationMitochondrion membrane. Cytoplasm. Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
    • Information by UniProt
    • Database links
    • Alternative names
      • bA528A10.3 antibody
      • E3 ubiquitin protein ligase RNF144B antibody
      • E3 ubiquitin-protein ligase RNF144B antibody
      • IBR domain containing 2 antibody
      • IBR domain containing protein 2 antibody
      • IBR domain-containing protein 2 antibody
      • IBRDC 2 antibody
      • IBRDC2 antibody
      • KIAA0161 antibody
      • MGC71786 antibody
      • OTTHUMP00000016079 antibody
      • OTTHUMP00000016080 antibody
      • OTTHUMP00000039360 antibody
      • p53 inducible RING finger protein antibody
      • p53-inducible RING finger protein antibody
      • p53RFP antibody
      • PIR2 antibody
      • R144B_HUMAN antibody
      • Ring finger 144B antibody
      • RING finger protein 144B antibody
      • RNF 144B antibody
      • RNF144B antibody
      see all

    Anti-IBRDC2 antibody images



    • Predicted band size : 34 kDa

    References for Anti-IBRDC2 antibody (ab57246)

    This product has been referenced in:
    • Du W  et al. Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc). J Biol Chem 285:37436-44 (2010). WB ; Human . Read more (PubMed: 20864535) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab57246.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"