General notesab94130 is a 293T cell transfected lysate in which Human ICAD has been transiently over-expressed using a pCMV-ICAD plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: Inhibitor of the caspase-activated DNase (DFF40).
Similarity: Contains 1 CIDE-N domain.
PTM: Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
Phosphorylated upon DNA damage, probably by ATM or ATR.