Specificityab82409 reacts with ICAM1 expressed on activated endothelial cells, T
lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesFlow Cyt: Use 10µl for 106 cells or 100 ml of whole blood.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational modificationsMonoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Antigen identified by monoclonal antibody BB2 antibody
BB 2 antibody
CD 54 antibody
Cell surface glycoprotein P3.58 antibody
Human rhinovirus receptor antibody
ICAM 1 antibody
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor antibody
Intercellular adhesion molecule 1 antibody
Major group rhinovirus receptor antibody
MALA 2 antibody
MyD 10 antibody
Surface antigen of activated B cells, BB2 antibody
References for Anti-ICAM1 antibody [1H4] (PerCP) (ab82409)
This product has been referenced in:
Williams DT et al. Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites. J Gen Virol85:731-8 (2004).
Read more (PubMed: 14993659) »