The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesELISA: Use at an assay dependent dilution. Dectection only.
Flow Cyt: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational modificationsMonoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Antigen identified by monoclonal antibody BB2 antibody
BB 2 antibody
CD 54 antibody
Cell surface glycoprotein P3.58 antibody
Human rhinovirus receptor antibody
ICAM 1 antibody
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor antibody
Intercellular adhesion molecule 1 antibody
Major group rhinovirus receptor antibody
MALA 2 antibody
MyD 10 antibody
Surface antigen of activated B cells, BB2 antibody
References for Anti-ICAM1 antibody [6.5B5] (ab33090)
This product has been referenced in:
Burton VJ et al. Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood117:333-41 (2011).
Read more (PubMed: 20724539) »
Montefort S et al. Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects. Eur Respir J5:815-23 (1992).
Read more (PubMed: 1379941) »