Overview

  • Product name
    Anti-ICAM1 (phospho Y512) antibody
    See all ICAM1 primary antibodies
  • Description
    Rabbit polyclonal to ICAM1 (phospho Y512)
  • Specificity
    The antibody detects endogenous levels of ICAM-1 only when phosphorylated at tyrosine 512.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ICAM1.

  • Positive control
    • WB: HeLa cells treated with TNF alpha

Properties

Applications

Our Abpromise guarantee covers the use of ab51033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
ELISA 1/40000.

Target

  • Function
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. ICAM family.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen identified by monoclonal antibody BB2 antibody
    • BB 2 antibody
    • BB2 antibody
    • CD 54 antibody
    • CD_antigen=CD54 antibody
    • CD54 antibody
    • Cell surface glycoprotein P3.58 antibody
    • Human rhinovirus receptor antibody
    • ICAM 1 antibody
    • ICAM-1 antibody
    • ICAM1 antibody
    • ICAM1_HUMAN antibody
    • intercellular adhesion molecule 1 (CD54), human rhinovirus receptor antibody
    • Intercellular adhesion molecule 1 antibody
    • Major group rhinovirus receptor antibody
    • MALA 2 antibody
    • MALA2 antibody
    • MyD 10 antibody
    • MyD10 antibody
    • P3.58 antibody
    • Surface antigen of activated B cells, BB2 antibody
    see all

Anti-ICAM1 (phospho Y512) antibody images

  • All lanes : Anti-ICAM1 (phospho Y512) antibody (ab51033) at 1/500 dilution

    Lane 1 : Hela cells treated with TNF alpha at 20ng/mL for 5 minutes
    Lane 2 : Hela cells treated with TNF alpha at 20ng/mL for 5 minutes with Immunizing peptide


    Predicted band size : 57 kDa

References for Anti-ICAM1 (phospho Y512) antibody (ab51033)

This product has been referenced in:
  • Xu S  et al. Caveolin-1 scaffolding domain promotes leukocyte adhesion by reduced basal endothelial nitric oxide-mediated ICAM-1 phosphorylation in rat mesenteric venules. Am J Physiol Heart Circ Physiol 305:H1484-93 (2013). Read more (PubMed: 24043249) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab51033.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up