Overview

  • Product nameAnti-ICAM2 antibody [mIC2/4 (3C4)] (Biotin)
    See all ICAM2 primary antibodies
  • Description
    Rat monoclonal [mIC2/4 (3C4)] to ICAM2 (Biotin)
  • ConjugationBiotin
  • SpecificityMurine CD102 is a glycosylated cell surface protein that is broadly expressed on most leucocytes and is constitutively expressed on endothelial cells. CD102 interacts with the CD11a/CD18 integrin LFA-1.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation. COS cells transfected with murine ICAM-2.

  • General notes


    Clone mIC2/4 is reported to inhibit interactions between CD102 and LFA1.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.9% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesPurified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
  • Primary antibody notesClone mIC2/4 is reported to inhibit interactions between CD102 and LFA1.
  • ClonalityMonoclonal
  • Clone numbermIC2/4 (3C4)
  • MyelomaP3x63-Ag8.653
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab33703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/1 - 1/5.

Use 10µl of suggested working dilution to label 106 cells.





ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • RelevanceICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin like C2 type domains, and bind to the leukocyte adhesion LFA1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA1 dependent cell adhesion. It mediates adhesive interactions important for antigen specific immune response, NK cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
  • Cellular localizationMembrane; Single-pass type I membrane protein
  • Database links
  • Alternative names
    • CD102 antibody
    • CD102 antigen antibody
    • ICAM 2 antibody
    • Intercellular adhesion molecule 2 antibody
    • Ly60 antibody
    see all

References for Anti-ICAM2 antibody [mIC2/4 (3C4)] (Biotin) (ab33703)

This product has been referenced in:
  • Soede RD  et al. LFA-1 to LFA-1 signals involve zeta-associated protein-70 (ZAP-70) tyrosine kinase: relevance for invasion and migration of a T cell hybridoma. J Immunol 163:4253-61 (1999). Read more (PubMed: 10510363) »
  • Xu H  et al. Characterization of murine intercellular adhesion molecule-2. J Immunol 156:4909-14 (1996). Read more (PubMed: 8648141) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"