SpecificityMurine CD102 is a glycosylated cell surface protein that is broadly expressed on most leucocytes and is constitutively expressed on endothelial cells. CD102 interacts with the CD11a/CD18 integrin LFA-1.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1 - 1/5.
Use 10µl of suggested working dilution to label 106 cells.
ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
RelevanceICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin like C2 type domains, and bind to the leukocyte adhesion LFA1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA1 dependent cell adhesion. It mediates adhesive interactions important for antigen specific immune response, NK cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Cellular localizationMembrane; Single-pass type I membrane protein
References for Anti-ICAM2 antibody [mIC2/4 (3C4)] (Biotin) (ab33703)
This product has been referenced in:
Soede RD et al. LFA-1 to LFA-1 signals involve zeta-associated protein-70 (ZAP-70) tyrosine kinase: relevance for invasion and migration of a T cell hybridoma. J Immunol163:4253-61 (1999).
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