Anti-ICOS antibody [7E.17G9] (ab95630)
Key features and details
- Rat monoclonal [7E.17G9] to ICOS
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2b
Overview
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Product name
Anti-ICOS antibody [7E.17G9]
See all ICOS primary antibodies -
Description
Rat monoclonal [7E.17G9] to ICOS -
Host species
Rat -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Mouse ICOS cDNA and ICOS hexahistidine fusion protein.
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Positive control
- Three day ConA activated BALB/c splenocytes or Mouse splenocyte suspensions
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
7E.17G9 -
Isotype
IgG2b -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab95630 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Flow Cyt |
Use 0.06-1µg for 105-8 cells.
A 100 µl volume is recommended for staining the cell sample.
ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
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Notes |
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Flow Cyt
Use 0.06-1µg for 105-8 cells. A 100 µl volume is recommended for staining the cell sample.
ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
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Target
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Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. -
Tissue specificity
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. -
Involvement in disease
Immunodeficiency, common variable, 1 -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Post-translational
modificationsN-glycosylated. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 54167 Mouse
- SwissProt: Q9WVS0 Mouse
- Unigene: 42044 Mouse
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Alternative names
- Activation inducible lymphocyte immunomediatory molecule antibody
- Activation-inducible lymphocyte immunomediatory molecule antibody
- AILIM antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab95630 has not yet been referenced specifically in any publications.