General notesab94214 is a 293T cell transfected lysate in which Human ID2 has been transiently over-expressed using a pCMV-ID2 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more detailed how the transfected lysate was prepared view preparation notes
BackgroundDevelopmental stage: Found in most early fetal tissues but not in the corresponding mature tissues.
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain.
Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system.