Overview

  • Product nameAnti-IFI16 antibody
    See all IFI16 primary antibodies
  • Description
    Rabbit polyclonal to IFI16
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 101-150 (EAGPATPTST TSHMLASERG ETSATQEETS TAQAGTSTAQ ARTSTAQAGT) of Mouse IFI16 (NP_032355).

  • Positive control
    • Mouse lung lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 69 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceInterferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain, transcriptional regulatory domain and DAPIN/PAAD domain. IFI16 has three isotypes A, B, and C (85-95 kDa), which arise as a result of mRNA alternative splicing. All are phosphorylated on serine and threonine residues and can homo and heterodimerize. Expression is restricted to the nuclei of hematopoietic cells, fibroblasts and epithelial cells. IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell. Due to its localization in the nucleus, regulation of protein expression, and ability to bind DNA, it is assumed that IFI16 has a role in transcription regulation of cell differentiation. In addition, it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells.
  • Cellular localizationNucleus. Cytoplasm. Note: Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization.
  • Database links
  • Alternative names
    • IFI16 antibody
    • Gamma interferon inducible protein 16 antibody
    • Gamma-interferon-inducible protein Ifi16 antibody
    • IF16_HUMAN antibody
    • Ifi204 antibody
    • IFNGIP1 antibody
    • interferon activated gene 204 antibody
    • Interferon gamma induced protein IFI 16 antibody
    • Interferon gamma inducible protein 16 antibody
    • Interferon-inducible myeloid differentiation transcriptional activator antibody
    • p204 antibody
    • PYHIN2 antibody
    see all

Anti-IFI16 antibody images

  • Anti-IFI16 antibody (ab104409) at 1 µg/ml + Mouse lung lysate at 10 µg

    Predicted band size : 69 kDa

References for Anti-IFI16 antibody (ab104409)

This product has been referenced in:

See 1 Publication for this product

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