Overview

  • Product name
  • Description
    Rabbit polyclonal to IFITM1
  • Specificity
    ab70477 recognises all 3 isoforms of IFITMs (IFITM1, IFITM2 and IFITM3).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    HKEEHEVAVLGAPPSTILPRST

    , corresponding to N terminal amino acids 2-23 of Human IFITM1

Properties

Applications

Our Abpromise guarantee covers the use of ab70477 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 14 kDa.

Target

  • Function
    IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activition or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
  • Sequence similarities
    Belongs to the CD225 family.
  • Post-translational
    modifications
    Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 9-27 antibody
    • CD 225 antibody
    • CD 225 antigen antibody
    • CD225 antibody
    • CD225 antigen antibody
    • Dispanin subfamily A member 2a antibody
    • DSPA2a antibody
    • IFI 17 antibody
    • IFI17 antibody
    • IFITM1 antibody
    • IFM1_HUMAN antibody
    • Interferon induced protein 17 antibody
    • interferon induced transmembrane protein 1 (9-27) antibody
    • Interferon induced transmembrane protein 1 antibody
    • Interferon inducible protein 9-27 antibody
    • Interferon-induced protein 17 antibody
    • Interferon-induced transmembrane protein 1 antibody
    • Interferon-inducible protein 9-27 antibody
    • Leu 13 antibody
    • Leu 13 antigen antibody
    • Leu-13 antigen antibody
    • LEU13 antibody
    see all

References

This product has been referenced in:
  • Singh R  et al. Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol 85:208-16 (2011). Read more (PubMed: 20980524) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for contacting us.

IFITM1 and IFITM2 are well known and published proteins that acts as primordial germ cell markers. Please check the following publications;

http://www.ncbi.nlm.nih.gov/pubmed/16326387

http://www.i...

Read More

Thank you for your patience. Here is the homology between human and mouse for the following antibodies (based on the alignment of their immunogen sequences) ab55452: homology = 94% - crossreactivity very likely, but not tested ab57662: homolog...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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