The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: 1/1000. Predicted molecular weight: 110-130 kDa.
Note: the molecular weight of the IFNNAR1 varies with cell line
(different levels of glycosylation) in 293 and HeLa Cells; the mature form is ~110 - 130k.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionAssociates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Tissue specificityIFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
Sequence similaritiesBelongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains.
Post-translational modificationsPhosphorylated on tyrosine residues by TYK2 tyrosine kinase.