Anti-IFNAR1 (phospho S535 + S539) antibody (ab30571)

Overview

  • Product name
    Anti-IFNAR1 (phospho S535 + S539) antibody
    See all IFNAR1 primary antibodies
  • Description
    Rabbit polyclonal to IFNAR1 (phospho S535 + S539)
  • Specificity
    Specific for IFNAR1 protein phosphorylated at Ser535,539 in Western blots of human brain extracts.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Phosphopeptide corresponding to amino acid residues surrounding the phospho-535,539 of human Interferon-alpha Receptor, Type I, Subunit I (IFNAR1).

Properties

Applications

Our Abpromise guarantee covers the use of ab30571 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/1000. Predicted molecular weight: 110-130 kDa.
    Note: the molecular weight of the IFNNAR1 varies with cell line
    (different levels of glycosylation) in 293 and HeLa Cells; the mature form is ~110 - 130k.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
    • Tissue specificity
      IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
    • Sequence similarities
      Belongs to the type II cytokine receptor family.
      Contains 3 fibronectin type-III domains.
    • Post-translational
      modifications
      Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha type antiviral protein antibody
      • Antiviral protein, alpha-type antibody
      • Antiviral protein, beta-type antibody
      • AVP antibody
      • Beta type antiviral protein antibody
      • CRF2-1 antibody
      • Cytokine receptor class-II member 1 antibody
      • Cytokine receptor family 2 member 1 antibody
      • IFN alpha REC antibody
      • IFN alpha receptor antibody
      • IFN alpha/beta Receptor alpha antibody
      • IFN beta receptor antibody
      • IFN Interferon-beta receptor antibody
      • IFN-alpha/beta receptor 1 antibody
      • IFN-R-1 antibody
      • IFNAR antibody
      • Ifnar1 antibody
      • IFNBR antibody
      • IFRC antibody
      • INAR1_HUMAN antibody
      • Interferon (alpha beta and omega) receptor 1 antibody
      • interferon alpha and beta receptor subunit 1 antibody
      • Interferon alpha/beta receptor 1 antibody
      • Interferon alpha/beta receptor alpha chain antibody
      • Interferon beta receptor 1 antibody
      • interferon receptor 1 antibody
      • Interferon-alpha receptor antibody
      • Type I interferon receptor 1 antibody
      see all

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    References

    ab30571 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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