Overview

  • Product nameAnti-IFNAR2 antibody
    See all IFNAR2 primary antibodies
  • Description
    Goat polyclonal to IFNAR2
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    SYDSPDYTDESCT

    , corresponding to internal sequence amino acids 28-40 of Human IFNAR2 (NP_000865.2 ; NP_997467.1; NP_997468.1).

  • Positive control
    • Human Placenta and Prostate tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab104451 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionAssociates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
  • Tissue specificityIsoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
  • Sequence similaritiesBelongs to the type II cytokine receptor family.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
    Glycosylated.
  • Cellular localizationSecreted and Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Human interferon alpha/beta receptor antibody
    • IFN alpha REC antibody
    • IFN R antibody
    • IFN-a/ßR2 antibody
    • IFN-a/ßRß antibody
    • IFN-alpha binding protein antibody
    • IFN-alpha/beta receptor 2 antibody
    • IFN-R-2 antibody
    • IFNABR antibody
    • IFNAR2 antibody
    • IFNARB antibody
    • IFNR antibody
    • INAR2_HUMAN antibody
    • Interferon (alpha beta and omega) receptor 2 antibody
    • Interferon alpha binding protein antibody
    • Interferon alpha/beta receptor 2 antibody
    • Interferon alpha/beta receptor beta chain antibody
    • Type I interferon receptor 2 antibody
    • Type I interferon receptor antibody
    see all

Anti-IFNAR2 antibody images

  • ab104451, at 5 µg/ml, staining IFNAR2 in formalin-fixed, paraffin-embedded Human Placenta by Immunohistochemistry, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab104451, at 5 µg/ml, staining IFNAR2 in formalin-fixed, paraffin-embedded Human Prostate by Immunohistochemistry, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-IFNAR2 antibody (ab104451)

ab104451 has not yet been referenced specifically in any publications.

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