Overview

  • Product nameAnti-IFNAR2 antibody
    See all IFNAR2 primary antibodies
  • Description
    Chicken polyclonal to IFNAR2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified IFNAR2 intra cellular domain recombinant protein (15KD) (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab51545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/500 - 1/5000. Predicted molecular weight: 58 kDa. This antibody was tested using a 15kDA human IFNAR2 recombinant fragment only.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAssociates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
    • Tissue specificityIsoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
    • Sequence similaritiesBelongs to the type II cytokine receptor family.
    • Post-translational
      modifications
      Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
      Glycosylated.
    • Cellular localizationSecreted and Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Human interferon alpha/beta receptor antibody
      • IFN alpha REC antibody
      • IFN R antibody
      • IFN-a/ßR2 antibody
      • IFN-a/ßRß antibody
      • IFN-alpha binding protein antibody
      • IFN-alpha/beta receptor 2 antibody
      • IFN-R-2 antibody
      • IFNABR antibody
      • IFNAR2 antibody
      • IFNARB antibody
      • IFNR antibody
      • INAR2_HUMAN antibody
      • Interferon (alpha beta and omega) receptor 2 antibody
      • Interferon alpha binding protein antibody
      • Interferon alpha/beta receptor 2 antibody
      • Interferon alpha/beta receptor beta chain antibody
      • Type I interferon receptor 2 antibody
      • Type I interferon receptor antibody
      see all

    References for Anti-IFNAR2 antibody (ab51545)

    This product has been referenced in:

    See 1 Publication for this product

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