Anti-IFNAR2 antibody (ab56070)
Key features and details
- Rabbit polyclonal to IFNAR2
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-IFNAR2 antibody
See all IFNAR2 primary antibodies -
Description
Rabbit polyclonal to IFNAR2 -
Host species
Rabbit -
Tested applications
Suitable for: ELISA, ICC/IF, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
A synthetic peptide corresponding to C terminal residues of human IFNAR2 (Interferon-alpha/beta receptor beta chain precursor)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purified by antigen specific affinity chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab56070 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 57 kDa.
Two hour incubation. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
Notes |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 57 kDa. Two hour incubation. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
Target
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Function
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. -
Tissue specificity
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. -
Sequence similarities
Belongs to the type II cytokine receptor family. -
Post-translational
modificationsPhosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated. -
Cellular localization
Secreted and Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3455 Human
- Omim: 602376 Human
- SwissProt: P48551 Human
- Unigene: 708195 Human
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Alternative names
- Human interferon alpha/beta receptor antibody
- IFN alpha REC antibody
- IFN R antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab56070 has been referenced in 8 publications.
- Deng Y et al. Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses. EBioMedicine 70:103477 (2021). PubMed: 34284174
- Lundtoft C et al. Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling. PLoS Genet 16:e1009199 (2020). PubMed: 33104735
- Lloyd AF et al. Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nat Neurosci 22:1046-1052 (2019). PubMed: 31182869
- Cheng M et al. Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression. J Biol Chem 293:5975-5986 (2018). PubMed: 29496996
- Yang Q et al. Interferon-a inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh-7 cells transfected with hepatitis B virus X gene-expressing lentivirus. Exp Ther Med 14:5924-5930 (2017). PubMed: 29285141
- Happold C et al. Interferon-ß induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells. Mol Cancer Ther 13:948-61 (2014). PubMed: 24526161
- Hong XX & Carmichael GG Innate immunity in pluripotent human cells: attenuated response to interferon-ß. J Biol Chem 288:16196-205 (2013). Human . PubMed: 23599426
- Ghosh D et al. A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. Proc Natl Acad Sci U S A 105:11673-8 (2008). IP ; Human . PubMed: 18687895